MYO-RAD (RAD 140) Testolone
Hardcore Series MYO-RAD (RAD 140) Testolone
Benefits of RAD140
As I previously mentioned, RAD140 is truly a miracle SARM. It can be used for a variety of different uses. Just like YK-11, it can be used for both cutting and bulking cycles. I personally like to include testolone in all of my cycles. You can also “recomp” with RAD140 The goal of a recomp is to lose fat while you build muscle.
RAD140 Builds Muscle
If you’re looking to build some serious muscle mass, RAD140 is a great choice. Initial studies showed that patients taking testolone saw a large increase of muscle mass that was not found with the placebo group. For more serious muscle growth, you can consider stacking it with LGD 4033.
RAD140 BURNS FAT
Another positive effect of RAD140 is it’s ability to burn fat. It’s very similar to testosterone in this aspect. You can stack it with ostarine or cardarine to increase fat loss in your cycle, but RAD140 works great as a standalone compound as well.
If you’re into cardio, you’re going to love RAD140. One of my favorite benefits of RAD140 is how it increases cardiovascular performance and elevates oxygen levels in the body. You will be able to run longer, train harder, and recover faster. Obviously, these are all important aspects when training to create the perfect body.
If you’re considering taking RAD140, you’ll want to know what the best dose to take is. I recommend taking a daily dose of between 20mg and 30mg. Like I always say, I recommend taking a smaller dose the first week to see how your body reacts. More is not always better when it comes to SARMs. Take 10mg a day for the first week, and if all is well, you can increase the dosage. Because testolone is mild on the body, you can run it up to 16 weeks if you’d like. Here is an example cycle template you can follow:
Week 1: 10mg per day.
Weeks 2, 3, and 4: 20mg per day.
Weeks 5 through 16: 30mg per day
Best SARMs For Recomp Cycles: Lose Fat and Build Muscle
It’s that time of year again. Summer is coming up, and you want to look your best. Maybe you spent all winter making gains and building up muscle. Regardless, using sarms for recomp can help you lose fat while gaining muscle.
In the past, “recomping” was a term reserved for people who could afford to spend thousands of dollars on dangerous steroids and HGH. It was thought in the past to be impossible to gain muscle and lose fat at the same time.
Thankfully, there’s some cutting-edge technology that’s been introduced for use by the general public. They’re called SARMs, and they are rapidly changing the game. Previously these were only available to extreme athletes. Now thanks to online sarms sources, anyone can buy these compounds on the internet.
In this article, we’re going to look at the best SARMs for recomp that will allow you to achieve a full body recomposition. Whether you need to lose some weight and cut up, or you need to pack on the muscle, this stack will help you do both. Let’s take a look!
💡 Tip: You can find high quality SARMs vendors on the Sarms.io Source List
How to do a recomp cycle on SARMs (the right way)
Before you start your taking a SARMs recomp stack, there are a few things that you should keep in mind. As excellent as these SARMs are, they’re not a magical pill that’s going to work overnight. You will still need to maintain a clean diet and a regular exercise routine. However, if you’re consistent with your stack dosage, your routine, and your diet, then you will achieve results.
Bad Diet = Bad Results
While you’re taking these SARMs your body is going to have some extra needs. In addition to eating healthy foods and staying away from the potato chips you’ll also need to:
- Drink at least a gallon of water a day to help your body stay hydrated and break down the SARMs.
- Eat a high-protein diet to make sure that you’re able to build the most amount of muscle
- Balance your carbs and your fat intake. Carbs are necessary for daily energy, but you need to eat healthy fats (mono and polyunsaturated) to stimulate your metabolism.
Training Regimen For Recomping
For a recomposition, you need to train for both fat loss and muscle gain. The best way to achieve that is to combine High-Intensity Interval Training into your regular weightlifting routine. HIIT will allow your body to shred fat. These workouts only last for 15-20 minutes at a time. Because of this, you won’t have to worry about them hurting your muscle gains.
HIIT is proven to increase fat loss in athletes who incorporate it in their training. I’ve had the best success with 3x sessions a week on top of my normal 5 day a week training routine. It’s brutal, but it’s not something I do more than 8 to 12 weeks at a time. When I’m not using HIIT, I switch to low intensity cardio (walking, cycling, etc).
Best SARMs for Recomp and Body Transformation
Now that you know some basic diet and training information let’s take a look at the best SARMs for recomp cycles. These sarms will allow you to achieve your full-body recomposition in record time.
This SARM is essential for a recomp and offers several great all-around benefits. Most of these benefits come from an increase in HGH and IGF-1 levels. It will also improve sleep quality. Your body will use the extra HGH and sleep to help recovery and burn fat while you rest.
MK 677 also helps to balance out your body’s Nitrogen levels which allows your body to lose fat and gain muscle at the same time. It will also increase your vascularity and give you a better “pump” when you are working out.
Read more about MK 677 >>
Cardarine is another compound that works great in recomp cycles. It was initially developed to help reduce cholesterol levels, but exercise scientists have found out that is has quite a few other benefits as well. For one, it boosts your natural metabolism levels which can lead to increased fat loss.
The second major benefit that Cardarine will give you is increased healing ability. This will lower the possibility of you sustaining a lasting injury from overtraining. This is very common with people who are trying to do a full-body recomp.
Read more about Cardarine >>
Sometimes called Stenabolic, this SARM is going to help you take your fat loss to the next level. It does this through a couple of different methods. The first is that it decreases your insulin levels. This means that your body is going to be far less likely to store fat in the first place.
The second thing that SR 9009 will do for you is that it will allow you to up your cardiovascular endurance. You will be able to do your HIIT workouts at a far higher intensity, and you will be able to keep up the fast pace for a longer amount of time. This will allow your body to get the most out of every cardio workout.
Read more about SR 9009 >>
This SARM is essential for your recomp stack. This is the chemical that’s going to allow your to build huge amounts of muscle in a short period. You will gain hard, dry, muscle, and enjoy enhanced training abilities. It’s one of the most popular sarms because it is consistent and has a relatively low side effect profile.
Read more about LGD 4033 >>
Basic SARMs recomp stack for beginners
This may be the first time that you’ve ever done a recomposition or may be the first time you’re using SARMs. If that’s the case, then I’ve made a good SARMs recomp stack for beginners. If you’re new to this whole thing, then you should start with a cycle of this before moving onto more my more advanced stack listed below.
|Week 1||Week 2||Week 3||Week 4||Week 5||Week 6|
Advanced SARMs recomp stack for extreme results
If you’re an experienced bodybuilder and you’ve had some experience with using SARMs for recomp cycles, then this is stack that you need to use. It is guaranteed to give you some incredible results.
|Week 1||Week 2||Week 3||Week 4||Week 5||Week 6||Week 7||Week 8|
Note: This is an extreme sarms recomping stack. It is not uncommon to swap out 10lbs of fat for 10lbs of muscle. People will accuse you of taking steroids. Only follow this stack if you are experienced!
The best way to get these SARMs is to head on over to our sarms source list and find a provider that has everything in stock. You can read real reviews from customers and even share your experience with sources!
How to get the best results on your recomp cycle
When you’re doing a SARM cycle, you need to stick to the recommended methods of dosing. If you try to diverge and do things your own way, then you may be sacrificing performance and gains.
Because most of these SARMs have short half-lives (especially the SR 9009), the smartest way to take this stack is to split it up between morning and night. You should take your full stack in the morning, but at half of the dosage that I listed above. Eat a healthy breakfast, and go about your day.
After you’ve done your daily workout and eaten your dinner, take the other half of your stack. This will ensure that you have a good flow of SARMs through your body at all hours of the day.
Although these aren’t necessary, they will help you out in the long run:
- Omega-3 Oil Capsules. These will help prevent joint injury during intense training sessions.
- Zinc 50mg. If you take one of these a day, it will boost your natural energy levels and cause an increase in testosterone which will lead to more gains.
- Multi-Vitamin. This will keep your immune system in good condition.
Post Cycle Therapy
Do you need a PCT after running a SARMs recomp stack?
After you’ve completed a full cycle of SARMs, then you will have pushed your body to its limits. Using multiple sarms for recomp can be very stressful on your HPTA system. Individual sarms don’t usually cause shutdown, but stacks can. This is especially true if you run sarms for a long period of time.
I recommend that you go pickup some nolvadex. It is sold under the generic name Tamoxifen. Take 20mg a day for 4 to 6 weeks following your stack. Many sources do not stock this, but it’s good to have on hand if you can find it.
Final words and sources cited in this article
If you’ve gotten out of shape, and want to achieve the best results in the shortest amount of time, then this SARMs recomp stack is the best way to get there. You’ll be able to drop the blubber and pack on pounds of high-quality muscle tissue.
If you have any other questions, please leave me a comment below!
RAD140 (Testolone) – Results, Clinical Trials & Reviews
RAD140 is a selective androgen receptor modulator (SARM) currently under development for potential use in treating muscle wasting disorders and hormone-receptor positive breast cancer.
For those that are just here find out where to buy accurately dosed, third party tested RAD140, these are the only companies I currently use for my own personal research:
(Greater Than 99% Purity: FTIR, HPLC, GC-MS, LC-MS & NMR Tested)
Science.bio – 10% off coupon code “DC10”
Chemyo – 10% off coupon code “DC10”
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Swiss Chems – 25% off coupon code “DC25”
What Is RAD140?
RAD140 is a selective androgen receptor modulator (SARM) developed by Radius Health, Inc.
There are several unofficial slang terms for RAD140 in the fitness community, one of the most popular being “Testolone”.
RAD140 has all of the hallmarks of an effective SARM, exhibiting a high affinity for the androgen receptor with tissue selective anabolic effects in muscle in bone, with a relatively minimal effect on prostate, seminal vesicles, and other androgen affected tissues [R].
RAD140 has a high level of oral bioavailability and demonstrated high in vivo tolerability [R].
It is still in the preclinical stages with recruitment occurring right now into its first phase 1 human trial, and has yet to be tested on humans [R].
In addition, it is often referred to as a potential alternative to testosterone replacement therapy in the recreational bodybuilding community.
Its potential efficacy in a hormone replacement therapy context is implied in some of the preclinical animal data, but the scientists also acknowledge the potential limitations of RAD140 when considering it being used in this capacity.
Its lack of aromatization is all that is needed to make a definitive judgment on its overall efficacy profile as a hormone replacement therapy alternative, which I will delve into later.
Recreational users are quick to label RAD140 as the “safe non-steroidal version of testosterone.”
This is because it doesn't require injections and hasn't exhibited any notable side effects in its preclinical data.
Obviously with no human data, it is extremely presumptuous to make a statement like this, and later in the article I will delve further into the limitations of RAD140, and SARMs in general.
RAD140 is purported by many to be a very versatile SARM that provides a complete replacement for testosterone replacement therapy (TRT), without any of the side effects.
Mechanism Of Action
RAD140 doesn’t require any injections as it has a high level of oral bioavailability [R].
After ingestion, RAD140 binds to androgen receptors in different tissues in the body which a high level of selectivity.
After binding to the androgen receptors, RAD140 exerts tissue-specific anabolic effects in muscle tissue and bone, and neuroprotective androgen-like effects in the brain, with a relative lack of stimulation in prostate and seminal vesicles [R].
RAD140 is a potent androgen agonist in the levator ani, and is also a much weaker partial antagonist on the seminal vesicles and possibly the prostate.
RAD140 demonstrated excellent affinity for the androgen receptor (Ki = 7 nM) [R].
To put this in perspective, the affinity for the androgen receptor for Testosterone in this preclinical model was 29 nM, and 10 nM for DHT.
In other words, RAD140 has a greater affinity to bind to the androgen receptor than Testosterone and DHT.
RAD140 does not aromatize into Estrogen, and does not undergo 5-alpha reduction into a more androgenic metabolite.
One thing that needs to be noted is RAD140's preclinical characterization referring to it as a “partial antagonist” in androgen affected tissues [R].
While this implies it is much less androgenic than all other SARMs, this is not necessarily the case.
Most other SARMs are classified as “partial agonists” in androgen affected tissues, and while RAD140 is classified in its preclinical profile as a partial antagonist, partial agonists may also be considered ligands which display both agonistic and antagonistic effects in affected tissues [R].
This is important because at a first glance the majority of readers will assume that RAD140 is the only SARM that has antagonistic effects on the prostate gland, and is therefore the most viable candidate for SARM therapy to date, which is not necessarily the case.
All androgen receptor ligands that have extremely selective functions indicative of a SARM have demonstrated partial agonist activity in the prostate gland, RAD140 included, despite what its preclinical profile may imply.
Increases Muscle Mass
RAD140 is very potent at low dosages and exhibited a mean weight gain of more than 10% in 28 days at only 0.1 mg/kg in a preclinical primate model [R].
In a preclinical rodent model assessing the efficacy of RAD140 in comparison to exogenous Testosterone Propionate, RAD140 significantly outperformed Testosterone in myotrophic/androgenic selectivity.
In this study, rats were castrated and either given placebo, 1 mg/kg of Testosterone Propionate or graded dosages of either 0.03 mg/kg, 0.1 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg or 10 mg/kg of RAD140.
The “sham” group are untreated rats that weren't castrated that serve as a reference guide for how much anabolic/androgenic activity occurs in a normal healthy rat with normal endogenous Testosterone and DHT levels.
After castrating the rats, muscle mass and prostate size decrease because there is no longer sufficient androgen stimulation occurring in the body, as there is no Testosterone or DHT being produced.
By using RAD140 or Testosterone, this study exhibits exactly how effective these two compounds are at replicating the anabolic activity necessary to maintain normal amounts of muscle and bone mass, and how much androgenic activity will occur in the prostate relative to that.
By referring to the figure above you can see that the lowest dosage of RAD140 capable of maintaining normal levels of anabolic activity in the body was the 0.3 mg/kg treated group.
While Testosterone at 1 mg/kg was able to outperform the 0.3 mg/kg RAD140 group in muscle growth, it stimulated prostate growth as well to a much greater extent.
For therapeutic purposes, RAD140 exhibits a greater efficacy profile at low dosages than Testosterone, as it's able to maintain normal amounts of muscle mass, but greatly decrease the amount of androgenic activity in the body.
The 3 mg/kg RAD140 treated group was able to replicate the same level of muscle tissue growth as the 1 mg/kg Testosterone treated group, with about half of the androgenic activity in the prostate.
It would be interesting to see how the same Testosterone treated group would respond if they were given Dutasteride to inhibit the 5-alpha reduction of Testosterone into DHT, and if that group would still exhibit a less favorable selectivity than the RAD140 groups.
For all we know, it could be more beneficial to use Testosterone concurrently with a 5-alpha reductase inhibitor rather than RAD140, especially considering Testosterone aromatizes into Estrogen, which is a severely limiting flaw of SARMs in general, but that all remains to be seen.
In a therapeutic context, RAD140 looks very promising based on the preclinical data given, and it blatantly has the ability to selectively increase muscle tissue, even at supraphysiological levels.
No direct fat loss was noted in the preclinical trials conducted on RAD140, however, as a human accrues more muscle mass, their basal metabolic rate will increase in parallel.
This is a given, therefore anything that can increase lean muscle mass in a human would theoretically increase total daily energy expenditure.
The net result of that would be an increase in the amount of calories expended just by having more muscle tissue via RAD140 usage, and greater overall fat loss.
Therefore, it is very likely that RAD140 can indirectly increase fat loss to some extent, dependent on the amount of muscle growth it induces.
Increases Bone Mineral Density
All SARMs that have reached human trials have shown the ability to inhibit bone turnover, stimulate bone formation, and retain bone mineral density in a state of catabolism [R].
While RAD140 hasn't gone into human testing yet, its tissue selective anabolic effects in bone have been demonstrated in preclinical animal models [R].
As exemplified via other more thoroughly studied SARMs like Ostarine and LGD-4033, these effects will very likely translate in humans just the same in further clinical trials.
Reduces Prostate Size
RAD140 has proven capable of exhibiting tissue selective anabolic effects in muscle and bone equivalent to that of a therapeutic dosage of Testosterone while simultaneously reducing prostate size by approximately 70% [R].
RAD140 has a much lower level of androgenicity in the body and simultaneously suppresses natural Testosterone production.
The net result of this in hypogonadal males would be a fulfilment of Testosterone's important functions, with a lack of androgenic activity.
The net result of this in healthy males with normal testosterone levels would be a drastic decrease in prostate size and androgenic activity, in parallel to natural testosterone suppression.
The reason being that healthy men still operate with a significant amount of androgenic activity occurring via their natural Testosterone production and its 5-alpha reduction to DHT.
When a healthy male has their endocrine system suppressed, they will produce less Testosterone (and consequently DHT as well), which will cause a dose dependent decrease in muscle size, bone mineral density, prostate size and the size of seminal vesicles.
This is what makes RAD140 and other SARMs so interesting, as they will suppress the endocrine system and can reduce systemic androgenic activity, while keep anabolic activity exactly the same, or even increasing it to supraphysiological levels, depending on the dosage used.
There are a variety of therapeutic applications in which a very selective potent agonist in muscle tissue with a far lower level of androgenic activity would be beneficial in a clinical setting, with just one of those being a potentially viable treatment for benign prostatic hyperplasia in men.
Neurodegenerative Disease Protection
SARMs target androgen receptors in different areas of the body, and RAD140 has also shown neuroprotective effects in the brain of androgen deficient rats [R].
Endogenous androgens are responsible for several important functions in the body and brain, the majority of which are mediated via androgen receptor activation [R].
In hormonally deficient rats RAD140 activated those androgen receptors in the brain and prevented neurodegenerative disease progression from occurring in the absence of sufficient endogenous androgens.
RAD140 was able to activate androgen receptors in the brain, protect hippocampal neurons from cell death, and induce anabolic activity in muscle tissue and bone as effectively as Testosterone, all with a near complete absence of stimulation in androgen affected reproductive tissues [R].
Suppresses Breast Cancer
The androgen receptor is frequently expressed in many estrogen receptor (ER)-positive, ER-negative, and triple-negative breast cancers.
As RAD140 facilitates its effects via the androgen receptor, assessing its potential clinical applications in this context was worth exploring.
In a preclinical study RAD140 significantly suppressed the growth and proliferation of breast cancer cells in in vivo and in vitro models of AR/ER+ breast cancer [R].
RAD140 has a promising preclinical profile, and Radius Health is currently in the process of recruiting 40 postmenopausal women with hormone receptor positive breast cancer into its first phase 1 clinical trial on humans [R].
The main goal of the study is to evaluate its safety profile, tolerability, and pharmacokinetic characteristics in hormone receptor positive breast cancer.
RAD140 Clinical Trials
One Phase 1 study on RAD140 has been conducted [R].
The Phase 1 trials are the first stage of testing in human subjects designed to assess safety, side effects, best dosage, and formulation method for the drug.
Dose Escalation Study In Estrogen Receptor Positive, HER2 Negative Breast Cancer
The first Phase 1 trial involving RAD140 was a dose escalation study with a 3 + 3 design conducted in 2017 on 16 postmenopausal women with hormone receptor positive breast cancer.
The primary objective was to determine its safety profile and the maximum tolerated dose of RAD140.
The secondary objectives were to evaluate pharmacokinetics and antitumor activity.
The median age of the 16 patients enrolled in the trial was 58 years old.
88% of them had visceral disease and 94% had androgen receptor positive tumors determined via immunohistochemistry.
6 patients were given 50 mg RAD140 orally once per day.
7 patients were given 100 mg RAD140 orally once per day.
The other 3 patients were given 150 mg RAD140 orally once per day.
The median time on treatment was 8 weeks, with a range of 1-25 weeks for the entire group of patients.
Over 30% of patients experienced an elevation of their ALT/AST levels, decreased weight/appetite, and constipation.
Dose-limiting toxicities (all grade 3 and reversible) included hypophosphatemia and elevated ALT/AST.
2 patients experienced hypophosphatemia, and they were both in the 150 mg dosage group.
2 patients in the 50 mg and 100 mg dosage groups experienced elevated ALT/AST.
No drug-related deaths occurred.
There was 1 partial response in the 100 mg dosage group and 2 patients with stable disease for over 12 weeks.
The time to partial response was 15.9 weeks and the duration was 8.6+ weeks.
SHBG levels decreased in all 12 of the patients evaluated.
PSA levels increased in 10 of the 14 patients evaluated, with the most notable increase occurring in the patient with a partial response to RAD140 treatment.
That patient remained on the treatment at the 7 month mark.
The provisional maximum tolerated dose of RAD140 was determined to be 100 mg dosed once per day orally.
Overall, RAD140 demonstrated an acceptable safety profile and exhibited preliminary evidence of target engagement and antitumor activity [R].
Is RAD140 As Strong As Steroids?
Yes, kind of…
RAD140 purportedly (not officially) has an anabolic:androgenic rating of 90:1 and partially antagonizes the negative effects of testosterone on the prostate.
The anabolic:androgenic ratio is essentially a ratio which exhibits how much anabolic activity a specific compound will exert in the body, and how much androgenic activity it will exert in the body.
Anabolic, meaning that they promote anabolism (cell growth), and androgenic (virilization), meaning that they affect the development and maintenance of masculine characteristics.
The androgenic:anabolic ratio of a compound is a very important factor when determining the potential clinical applications of it.
Initial steroid research sought to synthesize a compound which retained a high degree of anabolic activity, coupled with a lack of androgenic activity, the goal being to produce a compound with a high anabolic yet low androgenic effect.
Because steroids were intended for medical treatment, patients could include men and women, and even children.
The last thing you want to do is give a girl a bunch of testosterone so she can prevent muscle wasting, only to have her end up with a myriad of masculinizing side effects like the deepening of her voice, acne, clitoral enlargement, body hair growth, and all the other negative side effects associated with anabolic androgenic steroids.
The androgenic side effects of steroids in men aren't insignificant either.
The risk of Gynecomastia (man boobs), endocrine shutdown (infertility), testicle shrinkage, negative effects on cholesterol, increased risk of heart disease, among many other side effects are all very real side effects of anabolic androgenic steroids.
I'm not saying that these will absolutely happen at all, but there is a chance of them occurring with steroid use, with some of them still occurring with SARMs to a significant extent.
Considering this, it is obviously very important to synthesize compounds that have as low of a risk of any of these side effects occurring, while still maximizing the anabolic efficacy of the treatment given to patients.
Compounds with a high ratio of androgenic to anabolic effects are the drugs of choice in androgen-replacement therapy, but in the context of muscle and bone wasting prevention, compounds with a much higher anabolic/androgenic ratio are exponentially better candidates for treatment.
Based on the preclinical data, RAD140 has shown that even with a complete absence of testosterone it can still induce just as much anabolic activity in muscle and bone as testosterone would, with several-fold less androgenic activity.
This would consequently eliminate and replace the need for anabolic androgenic steroid use in degenerative musculoskeletal disease treatment.
In addition, RAD140 synergistically works alongside testosterone to induce greater amounts of muscle growth in the body if they are used concurrently, while simultaneously decreasing testosterone’s negative side effects on the prostate [R].
Is RAD140 The Strongest SARM To Date?
This is debatable as different SARMs act on the androgen receptor in different ways in different individuals.
In general, it is undeniable that RAD140 is very strong, and pound for pound it is one of the strongest SARMs on paper with a purported 90:1 anabolic:androgenic ratio.
It is formidable to LGD-4033 in terms of strength gains, although LGD-4033 seems to be a more potent overall muscle builder.
RAD140 seems to have a muscle hardening effect that isn't commonly reported with LGD-4033.
Increased muscular endurance from RAD140 is also reported to be one of its most redeeming traits.
The only SARM that seems to outperform RAD140 in terms of muscle building, strength gains, and muscle hardening simultaneously is S23.
However, S23 is more suppressive and has some odd side effects that aren't reported with RAD140.
RAD140 Reviews (Anecdotal/Recreational Reports)
RAD140 is one of the most popular SARMs in the fitness and bodybuilding community in the context of performance enhancement.
It is most commonly used to gain muscle mass and increase strength.
It is reported to also be very effective at increasing muscular endurance and overall stamina.
While other SARMs help with muscular endurance to some degree, RAD140 in particular seems to excel in its ability to increase endurance, stamina and speed.
This is not to be confused with Cardarine and SR9009, which are not SARMs.
RAD140 is not as effective as Cardarine at increasing cardiovascular endurance.
RAD140 is most commonly used for bulking, or in recomposition phases, and is often referred to as a dry gainer.
It creates a harder, dryer look similar to SARMs like S4 and S23.
Users often report a very noticeable aggression unique to RAD140 that is not notable in any other SARM except S23.
This increased aggression has made RAD140 a fairly popular pre-workout alternative in the bodybuilding community.
Dosages of 10 – 30 mg per day are commonly used in a recreational context for muscle building purposes.
There is no established therapeutic dosage of RAD140.
Pharmacokinetic samples collected for 144 hours after the 100 mg RAD140 single dose showed variable absorption with a half-life of approximately 60 hours [R].
The observed human steady-state pharmacokinetic exposure at 100 mg exceeds the pharmacokinetic exposure of the efficacious dose in mice of 10 mg/kg.
RAD140 Side Effects
One thing you will often read is how there have been no reported side effects of RAD140.
This is not the case, both anecdotally as well as in the limited clinical data.
Potential Ventricular Inflammation
Unpublished preclinical toxicology studies with RAD140 indicated that it induced focal inflammation of the right ventricle in male and female Sprague-Dawley rats [R].
With that being said, the same side effect was not noted in the male or female cynomolgous monkeys treated with RAD140, and preclinical rat models have some underlying issues in regards to cardiovascular risk.
Androgens cause 11beta-hydroxylase inhibition in rat adrenal glands.
Inhibiting this in rats causes an increase in the adrenal output of 11-deoxycorticosterone, which can cause cardiac lesions in rat hearts.
Also, in another preclinical rodent model, high dosages of RAD140 had a protective effect on the heart.
This was the first occurrence of rat cardiotoxicity reported for a SARM.
The data supports that the focal inflammation in the rat studies cannot be extrapolated to primates and humans, so it is very unlikely that this same outcome would occur in humans.
The fact that it didn't occur in monkeys with dosages as high as 1000 mg/kg/day is very reassuring that this outcome would be less likely to occur in humans, but it is notable nonetheless.
While RAD140 exhibits one of the most impressive myotrophic/androgenic preclinical profiles, it cannot be ignored that there was still blatant increasing androgenic activity in a dose dependent manner in all animal models.
Albeit limited due to the high level of tissue selectivity, RAD140 still exhibits androgenic activity in the body and will potentially lead to accelerated hair loss.
However, it could also potentially reduce hair loss if used at a dosage that suppressed endogenous androgens and/or antagonized endogenous androgens at the androgen receptors enough that the androgen load on the body was lower than baseline, while still fulfilling the anabolic functions that would have otherwise been fulfilled via endogenous Testosterone.
This does not exclude temporary shedding (acute telogen effluvium) which can be triggered by a hormonal fluctuation.
This is not to be confused with androgenic alopecia, which is caused by follicular miniaturization induced by androgens.
Based on the efficacy data comparing S1 to Finasteride, it is likely that RAD140 (if anything) would reduce the progression of hair loss at therapeutic dosages based on its tissue selectivity [R].
Anecdotally, recreational users report hair loss quite fairly frequently with RAD140 usage, however, this is with dosages that likely greatly exceed what the therapeutic dosage will be in a clinical setting.
Whether this hair loss in the bodybuilding community is real androgenic alopecia or just temporary shedding is unclear and would require more data.
While the risk is relatively low based on anecdotal reports, it is safe to say that all SARMs can cause gynecomastia (gyno) as they impact the Hypothalamus-Pituitary-Testes-Axis.
By binding harder to the androgen receptors than endogenous androgens, there can be a diversion of more endogenous Testosterone to aromatize into Estrogen.
Also, suppressing Testosterone production in itself can cause an imbalance in the ratio of endogenous androgens relative to endogenous Estrogen in the body, creating a hormone imbalance that encourages gynecomastia development.
Estrogen management would be prudent during any usage of SARMs.
Lowering Of Lipids
Just like any other SARM or anabolic steroid, RAD140 exhibits a dose dependent lowering of lipids (LDL, HDL, triglycerides) [R].
One commonality among all anabolic androgenic compounds is that they will all suppress HDL cholesterol (“good” cholesterol) in a dose dependent manner, and this has been consistently demonstrated in clinical trials conducted on SARMs as well [R, R].
Every single SARM that has been evaluated has exhibited this same dose-dependent suppression of lipids.
Just like anabolic steroids, SARMs have all consistently exhibited suppression of luteinizing hormone (LH) and follicle stimulating hormone (FSH) through the Hypothalamus-Pituitary-Testes-Axis.
The result of this is decreasing natural testosterone production in a dose-dependent manner [R].
Anecdotally, RAD140 is one of the most suppressive SARMs.
In a preclinical primate model assessing its effect on endogenous Testosterone production, young monkeys with testosterone levels between 600-800 ng/dL (similar to the average Testosterone level of 25-54 year old human males) were treated with RAD140 for 28 days.
In all treated monkeys, Testosterone levels dropped to about 50% of baseline, with the average Testosterone level decreasing to 200-300 ng/dL.
This occurred even with dosages as low as 0.01 mg/kg [R].
Increased Estrogen Or Decreased Estrogen
RAD140 does not aromatize into Estrogen, but it still has a large impact on the ratio of Testosterone:Estrogen in the body.
RAD140 binds to androgen receptors harder than endogenous androgens, and can encourage increased amounts of endogenous aromatization of Testosterone to Estrogen by occupying vacant receptor sites.
In addition, dose-dependent suppression of endogenous Testosterone levels can lead to a Testosterone:Estrogen imbalance.
The systemic elevation of Estrogen levels in the body is often misinterpreted as the result of prohormone laced SARMs.
High Estrogen Symptoms
- Acne, oily skin
- Erectile dysfunction
- Low libido
- Gynecomastia (man boobs)
- Water retention
- High blood pressure
- Enlarged prostate
- Shrunken testicles
- Sugar cravings
High dosages and/or long-term use of RAD140 can cause a decrease in systemic Estrogen levels.
This is facilitated through higher levels of endocrine suppression.
Estrogen facilitated physiological functions in the body are mediated through the aromatization of Testosterone into a sufficient amount of Estrogen.
If RAD140 usage suppresses endogenous Testosterone levels too low, it can result in Estrogen levels dropping as a consequence of the lack of aromatization occurring in the body in a suppressed state.
When Estrogen levels get too low, a new set of side effects can occur.
Low Estrogen Symptoms
- Dull weak orgasms
- Dry skin and lips
- Erectile dysfunction
- Low libido
- Mood swings
- Loss of appetite
Even at dosages 10 times higher than the efficacious dosage required to replicate the therapeutic anabolic benefits of Testosterone, RAD140 did not increase liver enzymes or exhibit any liver toxicity [R].
While this was just a preclinical animal model, it is promising for the development of RAD140 as other SARMs have shown potential liver toxicity concerns, albeit minimal at their therapeutic dosage amounts.
RAD140 users commonly report very blatant increases in aggression.
While this is anecdotal, it has occurred consistently enough in the bodybuilding community that it should be considered.
The interesting thing about this is that typically increased aggression only occurs when androgen index increases in the body.
This is why more androgenic steroids are commonly used pre-workout for a quick boost in aggression before training.
The fact that RAD140 is resulting in increased aggression in recreational users could potentially be indicative of some of the following outcomes:
- RAD140 isn't as selective for anabolic activity relative to androgenic activity in humans as it was in the preclinical animal studies
- The dosage humans are using recreationally is far higher than needed
- Their RAD140 is fake and is another hormone entirely
I believe the second potential outcome is the most likely reason.
Potential As A Hormone Replacement Therapy (HRT) Alternative For Men
RAD140 is often labeled in the recreational fitness and bodybuilding community as a potentially safer HRT alternative for men.
This has yet to be proven in clinical trials, and there is one massive inherent flaw that prevents RAD140 from being a standalone effective HRT alternative.
That is its lack of aromatization into Estrogen.
RAD140 does not aromatize into Estrogen, and also greatly suppresses endogenous Testosterone levels.
The net result of this is suboptimal Estrogen levels to support basic physiological functions in the male body, and a myriad of low-estrogen side effects with long term use.
Even if RAD140 was a viable alternative to Testosterone, it would either need to be used in conjunction with exogenous Testosterone, or Estrogen would need to be administered concurrently with RAD140.
RAD140 is not a viable standalone treatment for hormone replacement therapy.
While high levels of Estrogen can cause numerous negative side effects, low Estrogen levels can be just as deleterious in men.
RAD140 Bulking Cycle
In a calorie surplus RAD140 will promote more lean muscle gains than would otherwise be possible to gain naturally.
For use in a performance enhancing context, cycles like the following are commonplace among users.
MK-677 (Ibutamoren) and SARMs like S23 or LGD-4033 are commonly stacked alongside RAD140 in more involving performance enhancement bulking protocols.
RAD140 Cutting Cycle
In a calorie deficit RAD140 will retain much more lean muscle mass than would otherwise be possible naturally.
For use in a performance enhancing context, cycles like the following are commonplace among users (the length of this may vary depending on the user's individual timeline constraints for reaching a goal body fat percentage).
Cardarine (GW501516) and SARMs like Ostarine (MK-2866) or S4 (Andarine) are commonly stacked alongside RAD140 in more involving performance enhancement cutting protocols.
In less common cases, SARMs like ACP-105,AC-262536 or LGD-3303 are stacked alongside it.
RAD140 PCT (Post Cycle Therapy)
RAD140 is very suppressive and undoubtedly requires a PCT phase (post-cycle therapy) for efficient recovery.
The goal of a PCT phase would be to restore natural Testosterone production as quickly as possible and prevent low androgen or high Estrogen side effects from occurring.
Forgoing PCT will greatly increase the risk of muscle loss, fat gain, among all of the other negative side effects associated with low Testosterone levels.
How much time off should be taken after PCT should not be determined with the bro-science “time on = time off” equation, rather it should be dictated by individual specific factors and blood work.
Most RAD140 sources do not third party test their products, nor do they have any satisfactory level of quality control whatsoever.
I strongly advise that before you buy SARMs from a company online you thoroughly evaluate their track record, their third party test results, and how they are marketing their products in general.
These Are My Current Trusted/Go To Companies For Third Party Tested 99%+ Pure RAD140:
Disclaimer: The information included in this article is intended for entertainment and informational purposes only. It is not intended nor implied to be a substitute for professional medical advice. Prior to buying anything, check that it is compliant where you live with your current government laws.
We know your troubles all too well: You’ve been trying to build new muscle mass, but it just isn’t happening. Your weight gain is abysmal and you’re just thinking about throwing in the towel.
Most of our crew members have been in that same and exact situation, but it all changed once they started using Testolone. One of our team members managed to gain fifteen pounds of raw muscle in just one cycle, imagine that! He also lost some body fat to top it off, but the main spectacle was all the new muscle! You should have seen him; he was a completely new human being.
You can experience these same results and this RAD 140 review will steer you in the right direction!
RAD 140 Effects On The Body
There are a lot of RAD 140 effects on the body, Testolone even helps with concentration and cognition, but we’re more concerned about the impact it has on your bodybuilding career.
- Increased Power and Muscle Mass: There was a study done on primates which showed that they all gained a significant boost in power and they increased their muscle mass by a lot. While this study wasn’t replicated on humans, it’s still valuable since we’re so genetically close to monkeys.
- Increased Libido: You will turn into a teenager again, waking up with morning wood and all that. It’s going to be great if you have a significant other with whom you can share some passionate moments, as you’ll become both a beast in bed and in the gym.
- Helps You Lose Stubborn Body Fat: We had a guy in our crew that capped out at 13% body fat and couldn’t for the life of him stoop down to his wished level, 10%. Two cycles on Testolone were enough to grant him that wish, and best of all, he experienced zero side effects. The fat losing properties of RAD 140 are confirmed by the following study.
- Increases Energy: You will enjoy a much better time in the gym once you introduce RAD 140 to your body. You’ll be a lot bolder, aggressive and assertive. Many people smash their fitness goals with ease as the increased energy nudges them towards higher and higher planes.
- Prominent Veins: The fat loss induced by RAD 140 doesn’t just work on your stomach, it applies to your entire body. Your veins are going to be highly visible and people around you will be in awe of your hard work and determination!
RAD 140 Half Life, Dosage And Cycle
The RAD 140 half-life is around 17,5 hours, which means that taking it once a day is enough to get ahold of all the positive effects.
Your dosage should be between 5 to 15mgs, depending on your experience with Testolone and SARMs in general.
You should cycle RAD 140 for eight weeks, beginners on their first cycle can stop at week six, if they notice that the suppression is too much for them.
On the other hand, professionals may go up to ten weeks with Testolone, without experiencing any side effects.
RAD 140 VS LGD 4033
RAD 140 is a bit stronger than LGD 4033, but they have similar effects on the body as they are both SARMs that promote muscle growth, strength and stamina. If you’re a beginner on the fence about starting with one or the other, we personally recommend LGD 4033 as it is less likely to cause suppression in the body.
On the other hand, Testolone is known to cause Testosterone depletion and Post Cycle Therapy is mandatory. Intermediate and professional SARM users usually stack RAD 140 and LGD 4033 for even better results during a bulk.
The Testolone will work wonders on your raw mass and physique, while the Ligandrol will give you the energy needed to better perform during your workouts. It is recommended to take 10mgs of Testolone and 15mgs of Ligandrol for optimal results. The cycle shouldn’t last longer than eight weeks and PCT is an absolute must after doing this stack.
Four to six weeks of Nolvadex should be enough to turn things back to normal.
RAD 140 User Reviews Online – What Other People Say About It
There are many testimonies you can find online, but you have to watch out when reading them on websites that are vendors themselves. We’re not saying that their reviews are necessarily fake, but some might be hidden or altered to give the illusion that everything is fine.
We usually trust communities like Reddit, as their experiences are all from real users and fake reviews are easily spotted and downvoted to oblivion.
The first report we want to share with you comes from a Reddit user that tried to micro-dose Testolone to see if it would bestow him with any positive effects. He took 5mgs a day for seven weeks and he says that he felt ecstatic the whole time. Mood and libido were significantly enhanced, his lifts were all better and he felt a good pump in the gym. The user goes on to detail every week of his experience and you can read the rest of it here.
The second experience we found interesting also comes from Reddit where the original poster decided to share his first four weeks on RAD 140 with us. He claims that he didn’t feel much of a change in the first week, but that from week two onwards, energy was definitely up, pump was so amazing that you just want to keep going on and that he was feeling more sociable and positive in general. He did report a bit of a headache at the start of his cycle, but that’s to be expected, especially for first time users.
There’s a hundred more of these experiences that we could share with you, but we want this RAD 140 review to be as concise as possible. All the reviews seem to echo the thought that Testolone really works and that it has zero side effects attached to it. Some people even went as far as not taking PCT as they didn’t feel any suppression. As you can see, RAD 140 is used by a wide range of bodybuilders, it’s perfectly safe and there’s nothing to worry about.
The Best RAD 140 Stack(s)
We got a few combinations in mind when it comes to the best RAD 140 stack(s).
The first one is definitely between RAD 140 and Ibutamoren.
The RAD 140 will work its magic on your muscles and strength, while the Ibutamoren will give you a good night’s sleep (rest is important for muscle growth as well!) and it will increase bone density to support all the new muscle.
It’s the perfect combo for bulking up, you should take 10mgs of RAD 140 and 20mgs of Ibutamoren for eight weeks. PCT is required after this stack.
The second combo we have in store for you is between Ostarine and RAD 140. They work great together during a recomp as the Ostarine will see to it that you lose a ton of fat and weight, while the Testolone will net you lean muscle gains. One should take 10mgs of Testolone and between 20 to 25mgs of Ostarine for eight weeks.
PCT is also required for this stack, as RAD 140 can be suppressive.
The last stack should only be used by professionals in the field of SARMs and consists of three compounds: Ligandrol, Testolone and MK-677.
This stack will ensure that your fitness goals are fulfilled. It’s a great stack as you’ll gain a lot of muscle mass and strength, while also losing fat. You will also be energized throughout the cycle and your cognitive skills will see a significant uptrend.
Don’t do it for longer than eight weeks or you might experience side effects.
PCT is needed when you use this stack.
Possible Side Effects of Taking RAD 140
Many people worry about the side effects they might experience while taking RAD 140. It is a strong compound and that’s why many people are afraid that it will come to bite them back in the future.
The problem is, not one study has been performed on humans when it comes to RAD 140 so it’s hard to give you any scientific evidence of the words we’re about to say, but consider this: A vast majority of bodybuilders taking RAD 140 experienced zero side effects. Some didn’t even need a PCT cycle!
There are two things you have to worry about during your cycle with Testolone and those are headaches, which can occur in first-time users and are especially prominent during the first week of your cycle. The second thing to worry about is Testosterone suppression, which can be very real and dangerous if not mitigated with PCT. We usually recommend four to six weeks of Nolvadex or Clomid for the job and you will be good to go.
This is it, there are no other reported side effects of RAD 140. You can safely go out there and use the compound, just remember to preemptively plan out your PCT, so that suppression doesn’t catch you by surprise.
Where to Buy RAD 140
We’ve tested more than 10 SARMs companies, compared their purity rates and prices, scrutinized their customer service and much more to bring you four that were a cut above the rest.
Science.bio is a reputable US manufacturer of SARMs and many other compounds. They have recent lab results posted underneath their products and they price their SARMs quite fairly, with many bodybuilders naming them the most budget-friendly shop in the entire US.
RAD 140 at their shop can be found in liquid and powder form.
The liquid is a tad more expensive, with 30ml costing you around $50.00. Every ml equals to 10mgs of product, meaning that you get 300mgs of Testolone for the price you pay.
On the other side of the coin, we have the powder which is a bargain. You can get 1 gram for as low as $69.99. Their last batch shows a 100% purity rate for their RAD 140 powder!
If you’re from the US, you get free shipping if your total items amount up to $100.00 and foreigners get the same treatment if they buy up to 300$ worth of merchandise.
They ship on the same day, provided it’s a business day and it will take your goods around two to four days to arrive.
SwissChems are not another European vendor as many would presume, but are stationed in the US and sell a variety of compounds, including SARMs, peptides, nootropics and PCT supplements. They are the only vendor that sells injectable SARMs on this list, so if you’re feeling confident, you can take them up on that deal.
They sell Testolone as capsules, with 600mgs costing you $87.96 if you pay via cryptocurrency. The regular price is $109.95. Compared to Sciencebio, the prices and quality of their capsules are similar, meaning that location is going to be the deciding factor in your buying decision.
You have to pay around 7$ for shipping and that price only applies if you’re from the US. Otherwise, it’s going to be even steeper.
Shipping times are great, we got our goods in just two days of waiting.
This RAD 140 review has shown you how to use Testolone to bulk yourself up to a beast. Now that you know where to buy it, there is nothing stopping you from taking RAD 140 and having a shot at your personal gym records.
Have fun breaking your personal bests!
140 recomp rad
One of the newer SARMs is RAD-140, also known as Testolone. What is know about this compound is that it is very effective for muscle gains and bulking. In fact it is now considered as one of the best SARMs for muscle growth, making Testolone a common addition to a SARMs cycle.
Testolone has been created to potentially treat multiple health conditions including enlarged prostate, muscle wasting and as a testosterone replacement therapy.
Studies show it is very effective at mirroring the function of testosterone both anabolic and androgenic, but with a target of the muscle and bone we should not see the serious negative effects of the direct testosterone administration of anabolic steroids. That is what makes Testolone such an attractive option for those looking at an alternative performance enhancing compound.
Author’s Note: The following guide is based on my personal experience and does NOT promote the illegal use of SARMs. I am currently using this legal RAD-140 alternative.
In this guide, you'll learn:
What is RAD-140 (Testolone)?
RAD-140 is still an investigational drug, which means there’s a lot we still don’t know about it because of the early stages of research.
Testolone is still actively being researched including current clinical trials taking place right now, and these results are due to be released later in the year so it won’t be too long until we have a clearer idea particularly around the safety and toxicity aspects of this SARM which are an important part of the trials.
Testolone targets androgen receptors in the skeletal tissue and is considered as one of the better SARMs for building mass. But its the boost to strength that could be considered the hidden power of RAD-140, and potentially is the most important base function of this SARM that contributes to muscle gains: after all, if your strength has increased substantially then you’re going to see significantly bigger and faster gains from your workouts.
RADBULK | RAD-140
Legal RAD-140 Alternative
- Supports athletic performance, fat loss & strength
- Promotes enhanced vascularity & endurance
- Delivers a potent metabolism boost
By binding to targeted androgen receptors, Testolone is able to trigger the all important process of protein synthesis while also increasing retention of nitrogen; these aspects are going to help stimulate muscular growth as well as improved performance and endurance during intensive exercise.
This is a SARM that will cause suppression of testosterone even at low doses, so users will need to implement some post cycle therapy to restore the normal functioning of testosterone after a cycle.
RAD-140 Benefits (Effects)
You can expect to see superb lean muscle gains when using this SARM. It also improves strength so you’ll be lifting heavier and seeing your results faster than usual both thanks to the way Testolone helps the body build muscle, and because you’ll be supercharging your workouts.
Even at low dosages users of Testolone can expect impressive gains in muscle mass so you won’t need to use a lot of this compound. Expect it to take around four weeks until you start really feeling great strength increases, although some guys will see positive changes within just a couple of weeks.
From there you can expect to see your mass gains compounding as the SARM really kicks in throughout your cycle. It’s not impossible to gain 20 pounds of muscle with RAD-140, but your workouts and diet will need to support these gains otherwise no SARM will work for you. Additionally this is a SARM that stacks well with other SARMs if you really want to ramp up both performance and results.
The main reason people will use RAD-140 is for bulking as it has excellent muscle building capabilities but even more so, it is a powerful strength builder. The more strength you have, the more intense your workouts are going to be and that naturally leads to greater gains.
RAD-140 has a powerful anabolic effect but is targeted to just where you need it – in the muscles and bones – unlike steroids which impact the whole body. This means we can use Testolone with minimal side effects compared with anabolic steroids.
- Muscle Gains – Studies have proven that Testolone can live up to its intended purpose of increasing muscle mass and lean muscle weight gain. Some studies have shown that RAD140 is able to replicate the anabolic and androgenic effects of testosterone even at low doses. The amount of gains you can make is going to be highly individual and based on a range of factors from dosage to cycle length, diet and exercise program, and genetics. But there’s no doubt that Testolone’s ability to increase muscle mass is real, and while not as potent as steroids or even some other mass building SARMs in this regard, it will deliver high quality gains which you should be able to maintain well after your cycles. Muscle gains made with RAD140 will be dry and hard and you should notice increased vascularity thanks to the lack if fluid retention.
- Strength – The powerful and targeted androgen effects of Testolone will create a welcome rise in strength which you’re going to be able to take full advantage of to boost your pumps and general performance. With this extra strength can come some increased aggression in some people. It’s how you use this aggression that matters, and by channelling it into your workouts you’re going to see a big boost to performance and results from early on in your cycle.
- Fat Loss – Some research is being done into RAD-140’s potential for helping with fat loss so while we’re still waiting for specifics on exactly how Testolone could encourage fat burning, what is certain is that by increasing your lean muscle when using this SARM you are going to automatically become more efficient at getting rid of fat because of a higher metabolic rate. It’s a well known biological fat that the more lean muscle you have, the better the body is at burning fat even when you’re at rest. This is what makes Testolone very useful for recomping purposes where you’re looking to improve the ratio of muscle to fat.
- Mental Energy – Some users report a boost to mood and a reduction in fatigue and lethargy which is going to give you that extra kick to take on harder workouts and the motivation and energy you’ll need to maintain your planned workout program and dietary plan for the entire duration of your Testolone cycle.
These advantages do come with some downsides and the main one to consider is the suppression of testosterone which I will cover further in the side effects section below. For most users of this SARM, the above positive effects far outweigh the downsides and even experienced steroid users will find something in RAD140 to gain benefits from.
Testolone is a powerful SARM that does not require high doses to be effective. In fact lower doses are recommended even for the more advanced users, but there is still room to move if you want to slightly increase your dosage for better outcomes, while balancing any negative effects.
It’s more than possible to get some quality gains at just 4mg daily and this is where many beginners will choose to start. This low dose allows you to evaluate your results and monitor any adverse effects which will be much easier to address at low doses. Once you know how your body reacts to a low dose, you can consider increasing it in the later half of your cycle, or for your next Testolone cycle.
Testolone is a SARM that doesn’t have great popularity with women, and those considering its use should limit the dose to a very low level starting at 5mg daily with the possibility of increasing to 7.5mg. This will deliver excellent gains with women able to put on some quality lean muscle without worrying about the virilization effects of steroids.
Good results can be expected from Testolone at dosages as low as 10mg daily. Some people will increase this to 20mg daily, but it’s important to balance your dosage and side effects and new users of Testolone are best advised to start low and gauge your response to the point where you can increase the dosage if needed.
Any dosage higher than about 20mg per day will require you to do PCT, while you can likely recover well without PCT at the lower doses. A maximum of 10 weeks cycle length is recommended as the upper limit if you want to avoid more severe suppression and other side effects.
Typical RAD-140 Cycles
Testolone is known as a strength booster and enhanced strength is going to appeal to just about anyone with any goal. This means it is useful both as a solo compound and when stacked with something that can compound on its own effects; whether that be for bulking, cutting, enhancing athletic performance or body recomposition.
Some users will choose to use RAD-140 along with steroids but this is an advanced strategy. Those who are only wanting to stick with SARMs and SARM-like compounds will find four potential cycle suggestions for different goals below:
RAD-140 only cycle
With Testolone being such a powerful SARM it is possible to use it alone in a cycle and get great results. New users can start at a low dose of 10mg daily for the first two weeks and evaluate the effects – both positive and negative – and then increase the dose if desired up to 20mg. The cycle length is ideally limited to between 6 and 8 weeks to minimize testosterone suppression.
RAD-140 bulking cycle
A short and sharp 6 week cycle combining some of the most potent SARMs in a stack can deliver bulking results almost to rival those of steroids. In this case we can combine RAD-140 with YK-11 and LGD-4033 all with a dosage of between 10mg and 15mg daily each. Confident and advanced users can run this stack for 8 weeks or even 10 weeks but be prepared for a serious round of PCT following it.
RAD-140 cutting cycle
RAD-140 can add much to a cutting stack with its dry gains and ability to harden the physique, particularly near the end of a cycle. Two compounds that can combine with RAD140 in this stack are LGD-4033 and SR9009 which will combine to boost fat loss by improving efficiency of the metabolism. You can get by with awesome results on low doses of 10mg daily for both RAD-140 and LGD-4033.
SR9009 doses can start at 10mg and extend right to 40mg depending on how hardcore you plan to go with your cutting, with the latter needing to be administered two or three times daily due to its shorter half life. Run this cycle from 6 to 8 weeks for exceptional cutting outcomes.
RAD-140 recomping cycle
You want to improve your muscle to fat ratio when recomping so this cycle is a combination of making some gains while burning fat. An ideal compound to stack Testolone with for this purpose is S4 (Andarine). This combo will simultaneously reduce body fat while hardening the muscles, provided your diet is optimal and is rich in quality protein. You should run this cycle for at least 8 weeks, with up to 12 weeks possible as a maximum. An ideal S4 dose is 50mg daily while Testolone will be very effective at just 10mg daily, as you are trying to mostly maintain muscle rather than bulk up in this cycle.
RAD-140 Post Cycle Therapy
SARMs in general have a reputation of having no suppressive effect on testosterone, but this is not the case. Several SARMs are known to cause at least mild suppression, while Testolone is possibly the most suppressive SARM you can use.
This means you will very likely need to do some form of post cycle therapy once finishing a RAD140 cycle if you want to stimulate testosterone to start being produced by the body again.
Without PCT, normal testosterone function can take months to come back and during that time you will lose muscle, gain fat, lose strength and energy, have a low libido and low mood, and generally feel terrible and have poor health. So getting testosterone going again is critical after you’ve used RAD-140.
The amount of suppression you’ll experience with RAD140 is going to differ between individuals, and your dosage and cycle length will be big factors; but it’s not uncommon for guys to have a 50-70% reduction in testosterone. Many users will have a much lower level of suppression.
This can only be measured through blood testing, but at that level you are sure to notice some negative changes so you’ll want to have your PCT planned out. Steroid users favor drugs like Nolvadex and Clomid for PCT and these will more than cover your needs for the less harsh suppression caused by Testolone compared with steroids.
RAD140 vs Other SARMs vs Steroids
RAD140 can deliver some very similar effects to testosterone cycle and other steroids and is often thought of as one of the best alternatives to steroids, but it does so in very different ways.
It directly targets androgen receptors in muscles and bones, while steroids will imitate the entire effects of testosterone which has an impact on the whole body – this mass influx of hormones in to the body with steroids causes great muscle gains but also some very serious side effects. With SARMs like RAD140 the negative impacts are much less pronounced and sometimes non-existent.
The main differences between Testolone and SARMs generally compared with anabolic steroids are that most SARMs are going to be taken orally, so you do away with the need for injections. There are oral steroids as well, but these are often highly liver toxic while most SARMs have not shown to pose a serious risk of liver toxicity when used moderately.
When it comes to other side effects, the most common steroid related side effects that are both androgenic and estrogenic are sometimes experienced only mildly with SARMs and often not at all. Testolone does not cause estrogen conversion nor does it target androgen receptors elsewhere in the body so the familiar side effects in these two areas are not of great concern to Testolone users and users of other SARMs.
When it comes to results that can be achieved with Testolone and other SARMs versus steroids, we still have a lot to learn. But more and more bodybuilders are turning to SARMs and refining how to use them for best results. For many, the short and long term health impacts of anabolic steroids just don’t weigh up against the much lower risk of Testolone and other SARMs which have more than proven their ability to deliver quality results for bulking up, cutting and enhancing performance.
RAD-140 will propel your strength and contribute both directly and indirectly (through greater strength) to mass gains. And these will be nice dry gains without the added weight and bloat of water that you’ll get with most steroids.
Testolone is going to radically enhance your performance in the gym. You’ll feel stronger and able to workout at a higher intensity than before. By the second or third week of your cycle you can expect to be smashing through records, especially if this is your first time using a SARM. These gains in strength are going to continue through most of the cycle, although can begin to flatten out beyond 6 weeks which is one reason many will limit their cycle length to 8 weeks.
How much muscle can you gain with RAD-140 if your main goal is bulking? Well, it’s actually the big strength boost from Testolone that will contribute the most and it’s how you use that strength that’s going to determine results.
If you take on a seriously intense cycle of heavy workouts for 8 weeks you can potentially gain 10 to 15 pounds of lean mass during that cycle.
Those who don’t push themselves so hard at the gym might see 6 to 10 pound gains. It’s variable and there’s many factors involved; but once you do your first Testolone cycle you’ll know what you need to change for the next one to get even better results.
New users can assume that Testolone doesn’t come with any side effects as this is a common assumption about SARMs. It’s not the case though, and while you are right to assume you’re not going to have side effects that rival the intensity of those experienced with steroids, you still need to be aware of some of the negatives that can come with using RAD140. As with any compound, the higher your dosage and the longer you use it for is going to place you at higher risk of side effects.
A notable side effect of this SARM is an increase in aggression or a decrease in anger management; in other words, if you’re prone to a short temper then Testolone could possibly make it worse. This is usually a very individual side effect with some people not at all affected. Starting with a low dose and evaluating how you feel will help you keep this side effect in check if it becomes a problem.
Headaches are another potential side effect of RAD-140 but again, this is often seen at higher doses and can be mostly mitigated by keeping your dosages reasonable at no more than 20mg daily and by ensuring you’re buying high quality Testolone from a reputable source.
- Aggression – Some men will see this as a positive impact of Testolone, while others might find it to be a negative. It will largely depend on your personality and whether you are already prone to anger issues at times. If so, monitoring your dose and its effects in this area is important as it’s certainly higher doses that are going to increase the chances of aggression developing. Those guys who see this as a positive will be able to channel it into workouts to pump out more reps and sets and lift heavier weights.
- Testosterone Suppression – Don’t make the mistake of thinking that Testolone won’t be suppressive; in fact it’s one of the more suppressive SARMs we have. This will differ between individuals though and it can take a few weeks for effects of suppression to start being noticed, so be prepared early to prevent negative impacts. Many people will make use of small doses of testosterone to combat this suppression however that then requires using steroids. There are natural testosterone boosters available and the effects of these will differ wildly based on quality.
- Nausea and Other Symptoms – Some users have reported feeling nauseous on Testolone. Others have reported mild headaches or rashes and dizziness. These are mostly individual reactions and users can adjust the dosage accordingly to reduce or eliminate these effects. If they continue however at low doses and become worrying, it’s best to stop using Testolone and consider a different SARM instead.
The majority of Testolone users are going to find any side effects to be manageable and some guys will have no side effects at all. As long as you’re not taking massive doses and you’re being sensible about cycle length then these short lived negative effects are going to be greatly outweighed by the potential benefits.
Common Q&A Related to RAD-140 (Testolone)
Is Testolone legal?
Like all SARMs, Testolone is still a research drug so it’s not available for sale officially. The only way to get your hands on RAD-140 is through research labs. No matter how you obtain Testolone, it is still not legal to use in competitive sports and is listed as a prohibited substance. Some professional athletes have been caught through drug testing making use of SARMs like Testolone.
Does RAD-140 cause gyno?
RAD140 does not aromatize (convert testosterone to estrogen) so you’re very unlikely to have the worry of gyno developing like you do with steroids. Despite this, there are some reports from some users that mild symptoms of gyno have developed when they’ve used this SARM, although it is not known if very high doses are being used.
Potentially it is the suppression of testosterone and associated imbalance of hormones that have brought about this symptom in some users; again this is going to be a higher risk at high doses and long cycle lengths and will not rival the gyno that develops with steroids.
Is RAD-140 Safe?
No SARM can ever be confirmed as 100% safe. This is for several reasons: RAD140 like all SARMs is a research drug but it is one still in development and actively being tested, unlike other SARMs which had their research suspended. The fact that Testolone has no approval for human use means there is no long term data that can shed light on whether it is totally safe to use RAD140 regularly, or what effects it might have on the body over a longer term when used for performance enhancement. Anecdotal evidence from people who regularly use Testolone however have not noted any serious effects, and that is all we have to go on until further scientific research is completed.
Is RAD-140 suppressive?
Yes, Testolone is known as one of the more suppressive SARMs so you will need a PCT plan ready to go at the end of your cycle. The longer you use Testolone for, the higher you risk more severe testosterone suppression but in any case it is unlikely to be severe as that caused by steroid use unless you are using very high doses for cycle lengths beyond the recommended maximum.
Is RAD-140 safe to use though it is not approved by FDA?
There is always a risk in using any substance that has no approval for use in humans and limited studies on humans. As SARMs are experimental and research compounds, it’s not possible to fully understand the full effects, both positive and negative, on humans. So while many people use Testolone without any issues, the key is to moderate your dosage and cycle length and to closely monitor any side effects and how Testolone affects you as an individual.
Does RAD-140 cause water retention?
Testolone is known for its lack of estrogenic effects which means there is almost no chance of water retention happening. When you’re not retaining fluid you also eliminate the risk of increased blood pressure. This makes RAD-140 particularly appealing to steroid users who want to finish off a cycle with a compound that will dry and harden the muscles – and Testolone fits the bill perfectly.
Is a PCT mandatory with RAD-140?
Most users will want to do some post cycle therapy after using Testolone because it is will suppress testosterone to some extent. Allowing low testosterone to take hold will quickly kill your hard earned gains, have you putting on fat, losing your libido and generally falling into poor health. So your PCT plan should be just as important as your plan for your RAD140 cycle.
Does RAD-140 help burn fat?
By promoting strength and muscle gains, RAD-140 can lead to the easier and faster loss of fat. When you gain more lean muscle, the body is able to work at a higher metabolic rate and is able to burn fat even while you’re resting. So while it is not a specific fat burning SARM compared with some others, Testolone can still be very useful for cutting and particularly as it delivers a very dry, hardened and vascular physique which can make it valuable as a finishing compound when cutting or for pre-contest.
My Conclusion and Recommendation
This is a go-to SARM for many bodybuilders simply because we know it works so well for mass gaining and strength boosting.
RADBULK | RAD-140
Legal RAD-140 Alternative
- Supports athletic performance, fat loss & strength
- Promotes enhanced vascularity & endurance
- Delivers a potent metabolism boost
These are the two key areas that anabolic steroids are used for by serious weight lifters and while Testolone is not going to match your most hardcore steroids, it also won’t stress you out with the same side effects. Instead, this SARM provides a solid middle ground between excellent gains with minimal side effects.
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